Mechanistic insights into glycosidase chemistry

作者:Vocadlo David J*; Davies Gideon J
来源:Current Opinion in Chemical Biology, 2008, 12(5): 539-555.
DOI:10.1016/j.cbpa.2008.05.010

摘要

The enzymatic hydrolysis of the glycosidic bond continues to gain importance, reflecting the critically important roles complex glycans play in health and disease as well as the rekindled interest in enzymatic biomass conversion. Recent advances include the broadening of our understanding of enzyme reaction coordinates, through both computational and structural studies, improved understanding of enzyme inhibition through transition state mimicry and fascinating insights into mechanism yielded by physical organic chemistry approaches.

  • 出版日期2008-10