Design and optimization of hybrid of 2,4-diaminopyrimidine and arylthiazole scaffold as anticancer cell proliferation and migration agents

作者：Zhou, Wenbo; Huang, Anling; Zhang, Yong; Lin, Qingxiang; Guo, Weikai; You, Zihua; Yi, Zhengfang; Liu, Mingyao; Chen, Yihua^*

来源：European Journal of Medicinal Chemistry, 2015, 96: 269-280.

DOI：10.1016/j.ejmech.2015.04.027

• Hybridation
• Arylthiazoles
• Aminopyrimidines
• Antitumor growth and metastasis
• Structure-activity relationships

Therapeutics of metastatic or triple-negative breast cancer are still challenging in clinical. Herein we demonstrated the design and optimization of a series of hybrid of 2,4-diaminopyrimidine and arylthiazole derivatives for their anti-proliferative properties against two breast cancer cell lines (MCF-7 as human breast cancer and MDA-MB-231 as triple-negative breast cancer). More importantly, some of those compounds with potent antiproliferative activities also indicated excellent inhibitory activities against MDA-MB-231 cell migration. These results suggested that the new series of hybridation of arylthiazoles and aminopyrimidines could be identified and developed as novel highly potential anticancer agents against the triple-negative breast cancer as well as metastatic one in the future.

• 出版日期2015-5-26
• 单位华东师范大学