Assessment of vitamin D status and serum CrossLaps levels in adults with primary lactose malabsorption

作者：Enko D^*; Kriegshaeuser G; Stolba R; Mangge H; Brandstetter D; Mayr N; Forstner T; Halwachs Baumann G

来源：European Journal of Clinical Nutrition, 2016, 70(9): 1000-1003.

DOI：10.1038/ejcn.2016.66

BACKGROUND/OBJECTIVES: Primary adult-type lactose malabsorption (PALM) is a widespread inherited autosomal recessive condition, which is considered to be associated with osteoporosis. This prospective study aimed at assessing the 25-hydroxyvitamin D (25(OH) D) status and serum CrossLaps levels in individuals with PALM and normal controls.
SUBJECTS/METHODS: All participants (n= 210) underwent genotyping for the LCT C/T-13910 polymorphism, 25(OH) D and CrossLaps measurements and clinical examinations. In addition, the anthropometric data (that is, height, weight and body mass index) were determined.
RESULTS: Fifty-five individuals with PALM (that is, LCT C/C-13910 homozygotes) showed lower 25(OH) D (mean: 24.95 +/- 10.04 vs 28.59 +/- 9.56 ng/ml, P= 0.018) and higher CrossLaps serum levels (mean: 0.46 +/- 0.31 vs 0.43 +/- 0.49 ng/ml, P= 0.251) compared with 155 normal controls (that is, LCT C/T-13910 hetero-or T/T-13910 homozygotes). Anthropometric data were similar between PALM probands and controls.
CONCLUSIONS: Individuals with PALM were found to have lower 25(OH) D and higher CrossLaps serum levels compared with normal controls. In order to preserve life-long bone health, routine 25(OH) D and CrossLaps serum measurements should be performed in individuals with PALM.

• 出版日期2016-9