Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoenergetic proton beamline

作者：Yogo A^*; Maeda T; Hori T; Sakaki H; Ogura K; Nishiuchi M; Sagisaka A; Kiriyama H; Okada H; Kanazawa S; Shimomura T; Nakai Y; Tanoue M; Sasao F; Bolton P R; Murakami M; Nomura T; Kawanishi S; Kondo K

来源：Applied Physics Letters, 2011, 98(5): 053701.

DOI：10.1063/1.3551623

Human cancer cells are irradiated by laser-driven quasimonoenergetic protons. Laser pulse intensities at the 5 x 10(19) W/cm(2) level provide the source and acceleration field for protons that are subsequently transported by four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66 MeV and a bunch duration of 20 ns. The survival fraction of in vitro cells from a human salivary gland tumor is measured with a colony formation assay following proton irradiation at dose levels of up to 8 Gy, for which the single bunch dose rate is 1 x 10(7) Gy/s and the effective dose rate is 0.2 Gy/s for 1 Hz repetition of irradiation. Relative biological effectiveness at the 10% survival fraction is measured to be 1.20 +/- 0.11 using protons with a linear energy transfer of 17.1 keV/mu m.

• 出版日期2011-1-31