Generation of cancer-specific CDS+ CD69+ cells inhibits colon cancer growth

作者：Lan, Bin^*; Zhang, Jian; Lu, Dong; Li, Wenqin

来源：Immunobiology, 2016, 221(1): 1-5.

DOI：10.1016/j.imbio.2015.08.010

• Colon cancer
• CD8 T cell
• Apoptosis
• Antitumor immunity
• Cancer mouse model

The therapy of colon cancer (Cca) is poor currently. The abnormality of immune function is recognized in cancer-bearing hosts. This study aims to inhibit Cca growth with the in vivo induction of Cca-specific CD8(+) CD69(+) T cell polarization. In this study, a mouse tumor model was created with a mouse colon cancer (Cca) cell line. The Cca-bearing mice were immunized with Cca extracts and alum (using as an adjuvant). The CD8(+) CD69(+) cell polarization status was analyzed by flow cytomety and enzyme-linked immunosorbent assay. The results showed that a Cca antigen-specific CD8(+) CD69(+) cells were induced in the Cca-bearing mice. The Cca growth was efficiently inhibited by the Cca-specific CD8(+) CD69(+) cell response. The Cca-specific CD8(+) CD69(+) cells were detected in the Cca mass and spleen, which had the ability to induce Cca cell apoptosis. In conclusion, the Cca-specific CD8(+) CD69(+) cell polarization can be induced in Cca-bearing mice, which can efficiently inhibit the Cca growth.

• 出版日期2016-1
• 单位福建医科大学