Acute myeloid leukemia, the 3q21q26 syndrome and diabetes insipidus: A case presentation

作者：Curley Cameron^*; Kennedy Glen; Haughton Anne; Love Amanda; McCarthy Catherine; Boyd Andrew

来源：Asia-Pacific Journal of Clinical Oncology, 2010, 6(2): 77-79.

DOI：10.1111/j.1743-7563.2010.01285.x

• 3q21q26 syndrome
• acute myeloid leukemia
• diabetes insipidus

Diabetes insipidus (DI) is a rare presenting complication of acute myeloid leukaemia (AML). Typically, the combination of DI and AML is associated with structural abnormalities of the neurohypophysis. We present a case of AML and DI presenting without any abnormalities of the neurohypophysis on radiological scanning and with normal cerebrospinal fluid examination. The AML karyotype at presentation was characterized by the presence of a t(3; 3)(q21; q26) translocation and monosomy 7. After treatment with induction chemotherapy, the patient achieved a complete remission and his DI resolved. At subsequent AML relapse, characterized by a complex karyotype without the t(3; 3)(q21; q26) translocation or monosomy 7, DI did not recur. Our case provides clinical support to the hypothesis that the t(3; 3)(q21; q26) translocation and/or monosomy 7 in AML may directly result in dysregulation of transcription factors resulting in development of DI in AML patients.

• 出版日期2010-6
• 单位河北医科大学