Differences in the reduction of blood pressure according to drug administration at activity hours or rest hours

作者：Ponte Marquez Paola Helena; Jose Sole Maria; Antonio Arroyo Juan; Matas Laia; Teresa Benet Maria; Roca Cusachs Alex

来源：Medicina Clinica, 2015, 144(2): 51-54.

DOI：10.1016/j.medcli.2013.12.018

• Ambulatory blood pressure monitoring
• Circadian profile
• Treatment efficacy

Background and objective: In this study, 123 recordings of blood pressure (BP) obtained by ambulatory BP monitoring were analyzed. These recordings were measured in 2011 in patients from a Spanish tertiary university hospital. All participating patients were treated with 2, 3 or 4 anti-hypertensive drugs. The main aim of this study was to determine differences in BP control, if any, depending on the medication schedule. Thus, BP levels were studied at 3 periods of the day: activity hours, rest hours and 24 h.
Patients and method: We compared subjects taking all anti-hypertensive agents during the day (n = 70, group 1) with those taking at least one at night (n = 53, group 2).
Results: Significant differences were found on diastolic BP, where group 2 patients had lower levels at activity, 24 h periods and sleep-time. Even if it was not statistically significant, lower levels of systolic BP from group 2 were also observed at activity and 24 h periods as well as lower levels of systolic, diastolic and mean BP at rest hours periods. There were also significant group differences in relation to the number of prescribed agents (with the mean being higher for group 2) and the type of agent (beta-blockers and calcium antagonists were more prevalent in group 2). Nevertheless, the multivariate regression analysis done taking into account these variables did not change the observed statistical significance.
Conclusion: The administration of anti-hypertensive drugs at night could be associated with lower BP levels.

• 出版日期2015-1-20