A Comparison of Nephrotoxicity of Contrast Medium in Elderly Patients who Underwent Renal or Peripheral Arterial Vascular Intervention

作者：Peng, Meng; Jiang, Xiong-jing^*; Dong, Hui; Zou, Yu-bao; Song, Lei; Zhang, Hui-min; Wu, Hai-ying; Yang, Yue-jin; Gao, Run-lin

来源：Internal Medicine, 2016, 55(1): 9-14.

DOI：10.2169/internalmedicine.55.5321

• iodixanol
• nephrotoxicity
• contrast-induced nephropathy
• peripheral arterial revascularization

Objective To compare the nephrotoxicity of iodixanol in elderly patients who underwent a renal artery intervention (RAI) with those who underwent an other peripheral vascular intervention (OPI).
Methods Three hundred fifty-four consecutive patients (>60 years old) received iodixanol during RAI (n=150) or OPI (n=204). The level of serum creatinine (SCr) was measured at the baseline, 24 hours, 48 hours, 72 hours and 1 month after intervention.
Results Within 72 hours after the intervention, the adjusted mean of the peak SCr increase was 11.22 umol/L [95% confidence interval (CI): 9.21-13.24] in the RAI group and 12.40 umol/L (95% CI: 10.7-14.09) in the OPI group. The difference in the peak SCr increase was -1.17 umol/L (95% CI: -3.94-1.60; p=0.406). Contrast-induced nephropathy occurred in 26 patients (17.3%) of the RAI group and in 27 patients (13.2%) of the OPI group (p=0.286). Patients who underwent an RAI showed no increased risk for contrast-induced nephropathy in comparison with patients who underwent an OPI [adjusted odds ratio (OR)=1.108; 95% CI: 0.540-2.273; p=0.780].
Conclusion The nephrotoxic effect of iodixanol in elderly patients who underwent RAI or OPI was comparable.

• 出版日期2016
• 单位中国医学科学院阜外医院; 中国医学科学院北京协和医院