High Expression of TNFSF13 in Tumor Cells and Fibroblasts Is Associated With Poor Prognosis in Non-Small Cell Lung Cancer

作者：Zhao Qian; Cai Qingshan; Jin Chun; Zhu Huijun; Li Feng; Wei Qiang; Xia Qiang; Zhu Min^*

来源：American Journal of Clinical Pathology, 2014, 141(2): 226-233.

DOI：10.1309/AJCP4JP8BZOMHEAW

• Non-small cell lung cancer
• Tumor necrosis factor ligand superfamily member 13 (TNFSF13)
• Tissue microarray
• Immunohistochemistry
• Overall survival

Objectives: To examine high expression of tumor necrosis factor ligand superfamily member 13 (TNFSF13), which is correlated with several malignancies.
Methods: TNFSF13 messenger RNA expression in tumor cells and fibroblasts in a cohort of patients with non-small cell lung cancer (NSCLC) was analyzed by quantitative real-time polymerase chain reaction and immunohistochemistry using a tissue microarray.
Results: TNFSF13 expression was significantly higher in lung adenocarcinomas compared with squamous cell carcinomas (P = .022). High TNFSF13 expression in NSCLC stroma was related with low differentiation (P = .045) and sex (male > female, P = .005). Cox proportional hazards regression univariate and multivariable analysis revealed TNFSF13 expression in NSCLC tumor cells (P = .007) or fibroblasts (P = .027) as an independent prognostic factor in the 5-year overall survival rate.
Conclusions: Our findings indicate TNFSF13 is a prognostic factor in NSCLC and suggest TNFSF13 may be a novel therapeutic target for NSCLC.

• 出版日期2014-2
• 单位南通大学