Does dioxin exert toxic effects in humans at or near current background body levels?: an evidence-based conclusion

作者：Guzelian P^*; Quattrochi L; Karch N; Aylward L; Kaley R

来源：Human & Experimental Toxicology, 2006, 25(2): 99-105.

DOI：10.1191/0960327106ht594oa

• evidence-based toxicology
• dioxin
• cytochrome P450IA2

Evidence-based toxicology like evidence-based medicine, provides scientifically grounded evidence-based conclusions as distinguished from authority-based opinions. As an example, we address a proposition from the US Environmental Protection Agency's ( EPA) Draft Dioxin [ 2,3, 7,8-tetrachlorodibenzo-P-dioxin ( TCDD)] reassessment that: 'dioxin... can produce effects... at or near current background body burdens or intake levels'. Guided by a systematic, objective, and unbiased analysis of the available molecular, physiological, and clinical/epidemiologic data, in accordance with accepted principles of scientific logic, we reach the evidence-based conclusion that the proposition is rejected. When gaps in scientific knowledge necessitate formulation of opinions to meet preventive or precautionary goals, the reversion to authority should be explicitly acknowledged.

• 出版日期2006-2