An improved route for the synthesis of Rolloamide B

作者：Elagawany Mohamed^*; Ibrahim Mohamed A^*

来源：Tetrahedron Letters, 2016, 57(34): 3837-3840.

DOI：10.1016/j.tetlet.2016.07.044

• Rolloamide B
• IBCF
• Total synthesis
• Natural product
• Macrocycles

A high yielding method for the synthesis of the cyclic heptapeptide Rolloamide B has been described. An effective isobutyl chloroformate (IBCF) mediated direct coupling reaction was introduced to improve the synthetic route towards Rolloamide B. Furthermore, preliminary bioassays indicated potential activity against Gram-negative bacteria and fungi.

• 出版日期2016-8-24