科研之友
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摘要
The authors present and evaluate an original product in the armamentarium of the preparations for burns and wounds treatment, made solely on the basis of medicinal plants and natural ingredients. The ointment formulation comprises olive oil extract from a mixture of nine medicinal plants with wound healing activity (Calendula officinalis L., Matricariachamomilla L., Symphytumofficinale L., Hypericumperforatum L., Achilleamillefolium L., Arctiumlappa L., Plantago major L., Althaea officinalis L., Quercusrobur L.), sea buckthorn oil, lavender essential oil and as thickening agents, coconut oil, beeswax and conifer resin. The LC-MS analyses of the ethanolic extracts from the plant mixture and of the ethanolic re-extracts from oil plant mixture extract and from ointment have evidenced high levels of polyphenols like caffeic, chlorogenic, gallic and ferulic acids, as well as quercetin and rutin, all of which being known compounds with good wound healing activity. The neutral red assay has shown no cytotoxic effect on fibroblast NCTC cell line exposed to herbal extracts. Finally, the wound healing action of the submitted ointment has been clinically confirmed and highlighted by some case reports.
- 出版日期2016-4
