Stability studies of As4S4 nanosuspension prepared by wet milling in Poloxamer 407

作者：Bujnakova Zdenka^*; Dutkova Erika; Balaz Matej; Turianicova Erika; Balaz Peter

来源：International Journal of Pharmaceutics, 2015, 478(1): 187-192.

DOI：10.1016/j.ijpharm.2014.11.043

• Nanosuspension
• Stability
• Nanomilling
• Arsenic sulfide
• Particle size

In this paper the stability of the arsenic sulfide (As4S4) nanosuspension prepared by wet milling in a circulation mill in the environment of copolymer Poloxamer 407 was studied. The obtained As4S4 particles in nanosuspension were of similar to 100 nm in size. The influence of temperature and UV irradiation on the changes in physical and/or chemical properties was followed. Long-term stability was observed via particle size distribution and zeta potential measurements. Influence of UV irradiation was studied via UV-vis spectroscopy (UV-vis), photoluminicsence (PL) technique and Fourier transform infrared spectroscopy (FTIR) measurements. The best stability of the nanosuspension (24 weeks) was achieved when stored at 4 degrees C and in the dark.

• 出版日期2015-1-15