A Newly Designed Curcumin Analog Y20 Mitigates Cardiac Injury via Anti-Inflammatory and Anti-Oxidant Actions in Obese Rats

作者：Qian, Yuanyuan; Zhong, Peng; Liang, Dandan; Xu, Zheng; Skibba, Melissa; Zeng, Chunlai; Li, Xiaokun; Wei, Tiemin; Wu, Lianpin^*; Liang, Guang

来源：PLos One, 2015, 10(3): e0120215.

DOI：10.1371/journal.pone.0120215

• NF-KAPPA-B
• OXIDATIVE STRESS
• HEART-FAILURE
• INDUCED INFLAMMATION
• IN-VITRO
• HYPERTROPHY
• DYSFUNCTION
• INHIBITION
• NRF2
• EXPRESSION

Obesity is strongly associated with the cause of structural and functional changes of the heart in both human and animal models. Oxidative stress and inflammation play a critical role in the development of obesity-induced cardiac disorders. Curcumin is a natural product from Curcuma Longa with multiple bioactivities. In our previous study, in order to reach better anti-inflammatory and anti-oxidant dual activities, we designed a new mono-carbonyl curcumin analog, Y20, via the structural modification with both trifluoromethyl and bromine. This study was designed to investigate the protective effects of Y20 on obesity-induced cardiac injury and its underlying mechanisms. In high fat diet-fed rats, oral administration of Y20 at 20 mg/kg or curcumin at 50 mg/kg significantly decreased the cardiac inflammation and oxidative stress and eventually improved the cardiac remodeling by mitigating cardiac disorganization, hypertrophy, fibrosis and apoptosis. Y20 at 20 mg/kg showed comparable and even stronger bioactivities than curcumin at 50 mg/kg. The beneficial actions of Y20 are closely associated with its ability to increase Nrf2 expression and inhibit NF-kappa B activation. Taken together, these results suggest that Y20 may have a great therapeutic potential in the treatment of obesity-induced cardiac injury using Nrf2 and NF-kappa B as the therapeutic targets for treating obesity-related disorders.

• 出版日期2015-3-18
• 单位温州医科大学