Base-promoted intramolecular cyclization of N-alkyl, N-propargylic beta-enaminones for the synthesis of polysubstituted pyrroles

作者：Yang, Xiaobing; Wang, Yang; Hu, Fangzhong^*; Kan, Xiaoli; Yang, Chiming; Liu, Jiahui; Liu, Pei; Zhang, Qichun^*

来源：RSC Advances, 2016, 6(72): 68454-68459.

DOI：10.1039/c6ra14897b

• AU(I)-CATALYZED 6-ENDO-DIG CYCLOISOMERIZATION
• ONE-POT SYNTHESIS
• DERIVATIVES
• KNORR
• FURANS
• INHIBITORS
• PROPARGYLAMINOQUINONES
• DITHIOACETALS
• 2H-AZIRINES
• KETOESTERS

An efficient, mild, metal-free, base-mediated intramolecular cyclization of N-alkyl, N-propargylic beta-enaminones has been realized for the generation of polysubstituted pyrrole derivatives. This synthetic transformation tolerates a range of substituted N-alkyl, N-propargylic beta-enaminones in moderate to good yields.

• 出版日期2016
• 单位南阳理工学院; 南开大学