A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex DNA

作者：Hari Yoshiyuki^*; Akabane Masaaki; Hatanaka Yuri; Nakahara Motoi; Obika Satoshi

来源：Chemical communications, 2011, 47(15): 4424-4426.

DOI：10.1039/c1cc10138b

In order to expand target sequences in triplex DNA formation, the development of a nucleobase that recognizes a CG base pair in dsDNA was attempted. A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase was found to recognize a CG base pair with high sequence-selectivity.

• 出版日期2011