Antiplatelet prenylflavonoids from Artocarpus communis

作者：Weng Jing Ru; Chan Sheng Ching; Lu Yi Huang; Lin Hsien Cheng; Ko Horng Huey; Lin Chun Nan^*

来源：Phytochemistry, 2006, 67(8): 824-829.

DOI：10.1016/j.phytochem.2006.01.030

• Artocarpus communis
• Moraceae
• flavonoids
• Moraceae
• antiplatelet effect

Four flavonoids, dihydroartomunoxanthone (1), artomunoisoxanthone (2), cyclocomunomethonol (3) and artomunoflavanone (4), together with three known compounds, artochamins B (5), D and artocommunol CC (6) were isolated from the cortex of the roots of Artocarpus communis. The structures of 1-4 were determined by spectroscopic methods. The antiplatelet effects of the flavonoids, 1-3, 5 and 6 on human platelet-rich plasma (PRP) were evaluated. Of the compounds tested in human PRP, compounds 1, 5 and 6 showed significant inhibition of secondary aggregation induced by adrenaline. It is concluded that the antiplatelet effect of 1, 5 and 6 is mainly owing to an inhibitory effect on thromboxane formation.

• 出版日期2006-4
• 单位中国医科大学