Beyond alpha beta/gamma delta lineage commitment: TCR signal strength regulates gamma delta T cell maturation and effector fate

作者：Hayes Sandra M^*; Laird Renee M; Love Paul E

来源：Seminars in Immunology, 2010, 22(4): 247-251.

DOI：10.1016/j.smim.2010.04.006

• T cell development
• Signal transduction
• gamma delta T cell receptor
• Effector function

Signaling by the gamma delta T cell receptor (TCR) is required not only for alpha beta/gamma delta lineage commitment but also to activate and elicit effector functions in mature gamma delta T cells. Notably, at both of these stages, the signal delivered by the gamma delta TCR is more robust than the one delivered by either the preTCR or the alpha beta TCR. Recent studies now provide evidence that signaling by the gamma delta TCR is also required at other stages during gamma delta T cell development. Remarkably, the strength of the gamma delta TCR signal also plays a role at these other stages, as evidenced by the findings that genetic manipulation of gamma delta TCR signal strength affects gamma delta T cell maturation and effector fate. In this review, we discuss how a strong TCR signal is a recurring theme in gamma delta T cell development and activation.

• 出版日期2010-8