Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers

作者:Boudesocque Delaye Leslie; Agostinho Daniel; Bodet Charles; Thery Kone Isabelle; Allouchi Hassan; Gueiffier Alain; Nuzillard Jean Marc; Enguehard Gueiffier Cecile*
来源:Journal of Natural Products, 2015, 78(4): 597-603.
DOI:10.1021/np5003252

摘要

Two heterodimers comprising anthraquinone and methylbenzoisocoumarin moieties (1 and 2) were isolated, together with emodin and physcion from the tubers of Pyrenacantha kaurabassana. The structures of 1 and 2 were established by NMR spectroscopy, including the analysis of a 2D INADEQUATE spectrum. On the basis of the data obtained, the structures that were previously proposed in the literature for these compounds were revised. Compounds 1 and 2 showed antibacterial activity against three different strains of Staphylococcus aureus. Compound 2 also showed bactericidal activity against Helicobacter pylori.

  • 出版日期2015-4

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