Very Short Echo Time Improves the Precision of Glutamate Detection at 3T in H-1 Magnetic Resonance Spectroscopy

作者：Wijtenburg S Andrea; Knight Scott Jack^*

来源：Journal of Magnetic Resonance Imaging, 2011, 34(3): 645-652.

DOI：10.1002/jmri.22638

• magnetic resonance spectroscopy
• phase rotation
• very short echo time
• glutamate

Purpose: To examine the precision of glutamate detection using a very short echo time (TE) phase rotation STEAM (PR-STEAM) sequence.
Materials and Methods: Spectrosopic data were acquired from the anterior cingulate gyrus in nine healthy adults using 6.5-msec TE PR-STEAM, 40-msec TE PRESS, 72-msec TE STEAM, and TE-Averaging with an effective TE of 105 msec on a clinical 3T magnetic resonance imaging (MRI) system. All data were quantified using LCModel and reported as ratios relative to total creatine.
Results: Glutamate Cramer-Rao lower bounds were less than 8% for all sequences. The 6.5-msec TE PR-STEAM identified glutamate with the greatest precision (coefficient of variation (CV) of 7.1%), followed by TE-Averaging (CV of 8.9%), 40-msec TE PRESS (CV of 11.9%), and 72-msec TE STEAM (CV of 13.8%).
Conclusion: In the absence of spectral editing, glutamate is best detected in the human brain at 3T using very short TEs.

• 出版日期2011-9