Association between interleukin-10 rs1800872 G %26gt; T polymorphism and coronary artery disease: a case-control study and a meta-analysis

作者：Xuan Yang; Wang Li Na; Zhi Hong; Lu Zu Hong; Wei Ping Min

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(2): 2628-2641.

• Coronary artery disease
• SNP
• IL10
• meta-analysis
• molecular epidemiology

The goal of our study was to evaluate the genetic effects of interleukins genes polymorphisms on the risk of CAD through a case-control study and a meta-analysis. 826 CAD cases and 1153 CAD-free controls in east of China were collected to analyze the association of 28 SNPs in IL1A, IL1B, IL1f7, IL3, IL7Ra, IL17A, IL18, IL18R, IL18RAP, IL28B, IL15RA, IL15, IL9, IL10, IL12A, IL12B, and IL13 genes on the risk of CAD. The distributions of all genotypes were not significantly different between CAD group and control group (P > 0.05), except for IL1f7 rs3811047 G > A and IL10 rs1800872 G > T genetic variants. Our results showed that IL1f7 rs3811047 G > A, IL28B rs8099917 T > G and IL10 rs1800872 G > T polymorphisms were associated with the decreased risk of CAD in various comparison models. No significant association between the other 25 SNPs and the risk of CAD were found in this population. But the meta-analysis on IL10 rs1800872 G > T polymorphism and CAD risk, totaling 3038 CAD patients and 2732 controls, provided no convincing evidence for the genetic association (T vs. G: OR = 1.07, 95% CI 0.88-1.30, P = 0.510), even upon stratified analysis by ethnicity (Asian and Caucasian) or control selection criteria (normal angiography and symptom investigation). The discrepant overall result from previously published studies reflects publication bias or methodological problems. Future well-designed studies with large sample size should be conducted to validate our findings.

• 出版日期2016
• 单位东南大学