Disulfides with Anti-inflammatory Activity from the Brown Alga Dictyopteris membranacea

作者：Dimou Maria; Ioannou Efstathia^*; Daskalaki Maria G; Tziveleka Leto A; Kampranis Sotirios C; Roussis Vassilios^*

来源：Journal of Natural Products, 2016, 79(3): 584-589.

DOI：10.1021/acs.jnatprod.5b01031

Six new (1, 2, and 4-7) and two previously reported (3 and 8) disulfides, along with 4-butyl-2,6-cycloheptadienone, gamma-tocopherol, and delta-tocopherol, were isolated from an organic extract of the brown alga Dictyopteris membranacea, collected at Gerolimenas Bay, Greece. The structure elucidation of the isolated natural products was based on analysis of their spectroscopic data. Compounds 1, 3-6, and 8 were evaluated for their antibacterial and antiinflammatory activities. None of the compounds displayed antibacterial activity against two resistant strains of Staphylococcus aureus and one strain of Escherichia coli. In contrast, metabolite 5 was able to cause strong inhibition of NO production with an IC50 value of 3.8 mu M using an LPS stimulation assay.

• 出版日期2016-3