科研之友
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摘要
A simple, economic, accurate reverse phase isocratic reverse phase-HPLC method was developed for the prednisolone (10 mg) in tablet dosage form. A hypersil ODS C(18) (250 x 4.6 mm, packed with 5 micron) in an isocratic mode with mobile phase methanol:water (58:42) was used with flow rate (1.0 mL/min) and monitored at 254 nm. The retention times were 7.029 and 1.681 min for prednisolone and dexomethasone (internal standard), respectively. The linearity range was found to be 10-250 mu g/mL. The proposed method was validated.
- 出版日期2011-11
