科研之友
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摘要
The types of topoisomerase alterations in genomically diverse epidemic and sporadic strains of methicillin-and fluoroquinolone-resistant Staphylococcus aureus isolated from European hospitals between 1984 and 1994 were characterized. Convergent dual mutations in gyrA (codon 83, 84, or 88) and grlA (codon 79 and/or 80) were found in all strains exhibiting high-level resistance to ciprofloxacin (MIG, 16 to greater than or equal to 128 mu g/ml). In some epidemic strains, the resistant phenotype and genotype appeared in the 1990s and persisted thereafter.
- 出版日期1997-9
