Central inhibitory effects on feeding induced by the adipo-myokine irisin

作者：Ferrante Claudio; Orlando Giustino; Recinella Lucia; Leone Sheila; Chiavaroli Annalisa; Di Nisio Chiara; Shohreh Rugia; Manippa Fabio; Ricciuti Adriana; Vacca Michele; Brunetti Luigi^*

来源：European Journal of Pharmacology, 2016, 791: 389-394.

DOI：10.1016/j.ejphar.2016.09.011

• Irisin
• DA
• NE
• CART
• Orexin-A
• POMC

Irisin, the soluble secreted form of fibronectin type III domain containing 5 (FNDC5)-cleaved product, is a recently identified adipo-myokine that has been indicated as a possible link between physical exercise and energetic homeostasis. The co-localization of irisin with neuropeptide Y in hypothalamic sections of paraventricular nucleus, which receives NPY/AgRP projections from the arcuate nucleus, suggests a possible role of irisin in the central regulation of energy balance. In this context, in the present work we studied the effects of intra-hypothalamic irisin (1 mu l, 50-200 nmol/l) administration on feeding and orexigenic [agouti-related peptide (AgRP), neuropeptide Y (NPY) and orexin-A] and anorexigenic [cocaine and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC)] peptides in male Sprague-Dawley rats. Furthermore, we evaluated the effects of irisin on hypothalamic dopamine (DA), norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) concentrations and plasma NE levels. Compared to vehicle, irisin injected rats showed decreased food intake, possibly mediated by stimulated CART and POMC and inhibited DA, NE and orexin-A, in the hypothalamus. We also found increased plasma NE levels, supporting a role for sympathetic nervous system stimulation in mediating increased oxygen consumption by irisin.

• 出版日期2016-11-15