Apoliprotein E genotype is associated with apoliprotein B plasma levels but not with coronary calcium score in very elderly individuals in primary care setting

作者：Henriques Adriane D; Tonet Furioso Audrey C; Machado Silva Wilcelly; Freitas Wladimir M; Quaglia Luiz A; Santos Simone N; Cordova Claudio; Sposito Andrei C; Nobrega Otavio T^*

来源：Gene, 2014, 539(2): 275-278.

DOI：10.1016/j.gene.2014.01.077

• Apolipoprotein
• Lipid metabolism
• Atherosclerosis
• Primary prevention
• Aging

Background: Epidemiological surveys indicate the influence of polymorphisms of apolipoprotein (apo) E on plasma lipids and triglyceride-rich lipoprotein levels, with impact on atherosclerotic phenotypes. %26lt;br%26gt;Aim: We studied the association of classic genotypes of the apoE gene with clinical and biochemical risk factors for atherosclerosis in a segment of the very-old Brazilian individuals, with emphasis on the lipemic profile. %26lt;br%26gt;Methods: We performed cross-sectional analyses of clinical and laboratory assessments, including cardiac computed tomography, across epsilon 2, epsilon 3 and epsilon 4 carriers of the apoE gene with a convenience sample of 208 participants eligible for prevention against cardiovascular events. %26lt;br%26gt;Results: When non-epsilon 4 carriers were compared with epsilon 4 carrying subjects, lower levels of ApoB as well as ApoB/ApoA ratios were observed in the former group. Tests between apoE polymorphisms with other clinical/biochemical variables and those with arterial calcification showed no significant differences between groups. %26lt;br%26gt;Conclusion: The study suggests a possible atherogenic role of the epsilon 4 allele attributable to increased ApoB levels and ApoB/ApoA ratios among very-old subjects in primary care setting.

• 出版日期2014-4-15