An Epigenetic "LINK(RNA)'' to Pathological Cardiac Hypertrophy

作者：Liu Jianming; Wang Da Zhi^*

来源：Cell Metabolism, 2014, 20(4): 555-557.

DOI：10.1016/j.cmet.2014.09.011

Reinduction of fetal gene expression is characteristic of the failing adult heart. Han et al. (2014) demonstrate that a novel cluster of long noncoding RNAs, Myheart, protects the heart from pathological hypertrophy, involving a negative-feedback molecular circuit with the epigenetic Brg1 complex to inhibit fetal-gene reactivation.

• 出版日期2014-10-7