Awareness, apathy, and depression in Alzheimer's disease and mild cognitive impairment

作者：Jacus Jean Pierre^*

来源：Brain and Behavior, 2017, 7(4): e00661.

DOI：10.1002/brb3.661

• Alzheimer's disease
• apathy
• awareness
• depression
• mild cognitive impairment

IntroductionResults from studies on awareness disorders in Alzheimer's disease (AD) are controversial because the methodologies, the objects of awareness, and the patients' pathologic stage all vary. Our study aimed to compare scores and correlates of awareness according to the stage of the disease and the assessment method.
MethodsWe compared 20 mild AD patients to 20 mild cognitive impairment (MCI) patients, using the Patient Competency Rating Scale (PCRS; patient vs. caregiver report) and the Self-Consciousness Scale (rating scale). All patients underwent cognitive, psycho-affective and behavioral assessments (global cognition, executive functions, episodic memory, anxiety-depression, and apathy measures).
ResultsGroups were matched for age, education, and gender. They were comparable on the depression, anxiety, apathy and awareness scales (ps>.05), and differed for all cognitive variables (p<.05). Using the median split approach, greater apathy and lower depression were associated with poorer awareness on the Self-Consciousness Scale (respectively: odds ratio [OR]=4.8, p=.03; OR=4.84, p=.04), and the PCRS (only apathy: OR=9.3, p=.003). Greater apathy plus lower depression were associated with poorer awareness in both scales (PCRS: OR=40.5, p=.005; Self-consciousness scale: OR=28, p=.012).
ConclusionThese results evidence comparable awareness between AD and MCI patients. The correlates were more affective and behavioral than cognitive, independently from assessment method.

• 出版日期2017-4