Maternal tissue blood flow and oxygen saturation in pre-eclampsia and intrauterine growth restriction

作者：Karanam V L^*; Page N M; Anim Nyame N

来源：European Journal of Obstetrics & Gynecology and Reproductive Biology, 2014, 178: 148-152.

DOI：10.1016/j.ejogrb.2014.03.042

• Pre-eclampsia
• Intrauterine growth restriction
• Maternal tissue blood flow
• Oxygen saturation
• Strain gauge plethysmography
• Pulse oximeter

Objective: To investigate the hypothesis that impaired maternal tissue perfusion occurs in pre-eclampsia and intrauterine growth restriction (IUGR) and this correlates with maternal tissue oxygenation.
Study design: Strain gauge plethysmography was used to compare maternal calf blood flow during the third trimester in 16 women with pre-eclampsia, 6 women with 1UGR and 16 normal pregnant controls. A Mediaid iPOX pulse oximeter was used to measure maternal tissue oxygenation in the three groups and these were compared with tissue blood flow.
Results: Maternal tissue blood flow was significantly reduced in pre-eclampsia compared to the two other groups (p = 0.003). Blood flow was significantly reduced in pre-eclampsia compared to IUGR (p = 0.03). However there was no difference in blood flow between normal pregnancy and IUGR groups (p = 0.76). No significant difference was noted in maternal tissue oxygenation between the normal pregnancy, pre-eclampsia and IUGR groups (mean +/- S.E.M. [97.13 +/- 0.4, 96.69 +/- 0.33, 97.83 +/- 0.47 respectively], p = 0.26). No correlation was noted between blood flow and tissue oxygenation in the three groups of women.
Conclusion: We have demonstrated that reduced maternal resting tissue blood flow present in women with pre-eclampsia is not seen in women with IUGR and the reduction in blood flow in pre-eclampsia is not associated with changes in maternal tissue oxygenation.

• 出版日期2014-7