Iterative Synthesis of Oligo[n]rotaxanes in Excellent Yield

作者:Lewis James E M; Winn Joby; Cera Luca; Goldup Stephen M
来源:Journal of the American Chemical Society, 2016, 138(50): 16329-16336.
DOI:10.1021/jacs.6b08958

摘要

We present an operationally simple iterative coupling strategy for the synthesis of oligomeric homo- and hetero[n]rotaxanes with precise control over the position of each macrocycle. The exceptional yield of the AT-CuAAC reaction, combined with optimized conditions that allow the rapid synthesis of the target oligomers, opens the door to the study of precision-engineered oligomeric interlocked molecules.

  • 出版日期2016-12-21