Toll-like receptor 2 gene polymorphisms in Chinese Holstein cattle and their associations with bovine tuberculosis

作者：Zhao, Zhanqin; Xue, Yun^*; Hu, Zhigang; Zhou, Feng; Ma, Beibei; Long, Ta; Xue, Qiao; Liu, Huisheng

来源：Veterinary Immunology and Immunopathology, 2017, 186: 51-54.

DOI：10.1016/j.vetimm.2017.02.007

• Toll-like receptor 2 gene
• Bovine tuberculosis
• Single-nucleotide polymorphisms
• Chinese Holstein cattle

This study evaluated whether there was an association between polymorphisms within the Toll-like receptor 2 gene (TLR2) of Chinese Holstein cattle and susceptibility to bovine tuberculosis (BTB). In a case control study including 210 BTB cases and 237 control cattle, we found only two common single nucleotide polymorphisms (SNPs) within the entire coding region of the TLR2 gene, A631G (rs95214857) and T1707C (rs1388116488). Additionally, the allele and genotype distributions of A631G and T1707C were not different between case and control groups, indicated that these SNPs were not associated with susceptibility to BTB. These results suggested that polymorphisms in the TLR2 gene might not play a significant role in the BTB risk in Chinese Holstein cattle.

• 出版日期2017-4
• 单位河南大学