AMPed up to treat prostate cancer: novel AMPK activators emerge for cancer therapy

作者:Schiewer Matthew J*; Knudsen Karen E
来源:EMBO Molecular Medicine, 2014, 6(4): 439-441.
DOI:10.1002/emmm.201303737

摘要

Despite recent advances in the treatment for metastatic prostatic adenocarcinoma, clinical management of this tumor type remains a major challenge, and there is as of yet no durable cure for advanced disease. Developing pathways that could be co-targeted alongside the androgen receptor or that would otherwise thwart the development of the CRPC is a current translational and clinical priority. In this issue, a new study by Zadra et al identifies the energy sensor AMPK (5 ' AMP-activated kinase) as a viable therapeutic target in prostate cancer.

  • 出版日期2014-4