Antiviral activities of diarylheptanoids against influenza virus in vitro

作者：Sawamura Rie; Sun Yi; Yasukawa Ken; Shimizu Tomomi; Watanabe Wataru; Kurokawa Masahiko^*

来源：Journal of Natural Medicines, 2010, 64(1): 117-120.

DOI：10.1007/s11418-009-0372-2

• Alpinia officinarum
• Diarylheptanoid
• Antiviral activity
• Influenza virus

The anti-influenza A/PR/8/34 (H1N1) virus activities of ten diarylheptanoids isolated from Alpinia officinarum were examined using the MTT method. The 50% inhibitory concentration of each diarylheptanoid examined was clearly lower than its 50% cytotoxic concentration determined by the MTT assay and/or maximum non-cytotoxic concentration (MNCC) determined by the morphological change of cells. In particular, the influenza virus was more susceptible to 7-(4aEuro(3)-hydroxy-3aEuro(3)-methoxyphenyl)-1-phenyl-4E-hepten-3-one (3) and (5S)-5-hydroxy-7-(4aEuro(3)-hydroxyphenyl)-1-phenyl-3-heptanone (8) than the other diarylheptanoids. Thus, all diarylheptanoids exhibited potential antiviral activity against influenza virus in vitro.

• 出版日期2010-1