A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia

作者：Gubelin Harcha Walter; Barboza Martinez Julia; Tsai Tsen Fang; Katsuoka Kensei; Kawashima Makoto; Tsuboi Ryoji; Barnes Allison; Ferron Brady Geraldine; Chetty Dushen

来源：Journal of the American Academy of Dermatology, 2014, 70(3): 489-+.

DOI：10.1016/j.jaad.2013.10.049

• 5-alpha reductase
• 5-alpha reductase inhibitors
• androgenetic alopecia
• dutasteride
• finasteride
• male pattern baldness
• male pattern hair loss
• treatment

Background: Dihydrotestosterone is the main androgen causative of androgenetic alopecia, a psychologically and physically harmful condition warranting medical treatment. %26lt;br%26gt;Objective: We sought to compare the efficacy and safety of dutasteride (type 1 and 2 5-alpha reductase inhibitor) with finasteride (type 2 5-alpha reductase inhibitor) and placebo in men with androgenetic alopecia. %26lt;br%26gt;Methods: Men aged 20 to 50 years with androgenetic alopecia were randomized to receive dutasteride (0.02, 0.1, or 0.5 mg/d), finasteride (1 mg/d), or placebo for 24 weeks. The primary end point was hair count (2.54-cm diameter) at week 24. Other assessments included hair count (1.13-cm diameter) and width, photographic assessments (investigators and panel), change in stage, and health outcomes. %26lt;br%26gt;Results: In total, 917 men were randomized. Hair count and width increased dose dependently with dutasteride. Dutasteride 0.5 mg significantly increased hair count and width in a 2.54-cm diameter and improved hair growth (frontal view; panel photographic assessment) at week 24 compared with finasteride (P = .003, P = .004, and P = .002, respectively) and placebo (all P %26lt; .001). The number and severity of adverse events were similar among treatment groups. %26lt;br%26gt;Limitations: The study was limited to 24 weeks. %26lt;br%26gt;Conclusions: Dutasteride increased hair growth and restoration in men with androgenetic alopecia and was relatively well tolerated.

• 出版日期2014-3