A t(1;9)(q10;q10) translocation with additional 6q23 and 9q22 rearrangements in a case of chondromyxoid fibroma

作者：Dadfarnia Tahereh; Velagaleti Gopalrao V N; Carmichael Kelly D; Eyzaguirre Eduardo; Eltorky Mahmoud A; Qiu Suimin^*

来源：Cancer Genetics, 2011, 204(12): 666-670.

DOI：10.1016/j.cancergen.2011.11.005

• Chondromyxoid fibroma
• cytogenetics
• t(1
• 9) translocation

Chondromyxoid fibroma (CMF) is a rare cartilaginous tumor of bone. It typically presents in the long tubular bones and to a lesser extent in the small bones of the hands and feet of young adults. To date, several cytogenetic abnormalities have been described in association with CMF. We studied a phalangeal CMF from a 13-year-old female by cytogenetic methods. We found a novel unbalanced translocation between the long arms of chromosomes 1 and 9, resulting in loss of 1p. In addition, rearrangements involving the 6q23 and 9q22 regions were also observed. To our knowledge, this is the first report in the literature describing this novel chromosomal translocation in CMF.

• 出版日期2011-12