Disseminated cryptococcosis

作者:Bothra Meenakshi; Selvaperumal Prakash; Kabra Madhulika*; Joshi Prashant
来源:Indian Pediatrics, 2014, 51(3): 225-226.
DOI:10.1007/s13312-014-0356-5

摘要

Fungal infections, especially in immunocompetent children are uncommon causes of fever of unknown origin. A 5-year-old boy with prolonged fever and no evidence of immunosuppression. Ultrasound-guided retroperitoneal lymph node biopsy showed granulomas and intracytoplamic fungal yeasts; staining charactristics were suggestive of cryptococci. Clinical and radiological improvement was seen after treatment with amphoterecin-B. Disseminated fungal infection should be suspected as a cause of pyrexia of unknown origin after ruling out the commoner causes. Biopsy from enlarged lymph node or organomegaly may yield the diagnosis when non-invasive tests fail.