Do Different Arterial Stiffness Parameters Provide Similar Information in High-Risk Patients for Coronary Artery Disease?

作者：Kim Kyung Min; Yoo Byung Su^*; Ko Anna; Kim Jeong Min; Kim Hyun Sik; Lee Jun Won; Kim Jang Young; Youn Young Jin; Ahn Sung Gyun; Lee Seung Hwan; Yoon Junghan

来源：Korean Circulation Journal, 2013, 43(12): 819-824.

DOI：10.4070/kcj.2013.43.12.819

• Pulse wave velocity
• Coronary artery disease
• Arterial stiffness

Background and Objectives: The aim of our study was to compare the values of brachial-ankle pulse wave velocity (baPWV) measured with two different non-invasive methods as predictors of coronary artery disease (CAD) in patients who had undergone coronary angiography.
Subjects and Methods: From 6373 patients who visited our laboratory for non-invasive procedures, we enrolled 965 consecutive patients undergoing coronary angiography. Data for baPWV and peripheral augmentation index (pAI) were recorded. CAD was defined as greater than 50% stenosis of a major epicardial artery in a coronary angiogram. In addition, the severity of CAD was classified as: none/minimal or 1-, 2-, or 3-vessel disease, based on previous or current angiographic findings.
Results: Among 965 subjects, the mean age was 63.7 +/- 11.6 years, and 58.2% were male. Compared with subjects without CAD disease, those with CAD showed higher values of baPWV (16.6 +/- 3.5 m/sec vs. 15.9 +/- 3.4 m/sec, p<0.001), and lower values of pAI (73.5 +/- 15.9% vs. 76.0 +/- 15.7%, p = 0.01). When the severity of CAD was expressed as none/minimal or 1-, 2-, or 3-vessel disease, there was a significant association between the extent of CAD and baPWV (p < 0.001). In univariate analysis, high PWV and low pAI were associated with an increased prevalence of CAD (p < 0.001).
Conclusion: Increased baPWV and decreased pAI were associated with the presence of CAD in the elderly.

• 出版日期2013-12