MRI-based abnormalities in young adults at risk of adverse bone health due to childhood-onset metabolic & endocrine conditions

作者：McComb C; Harpur A; Yacoubian C; Leddy C; Anderson G; Shepherd S; Perry C; Shaikh M G; Foster J; Ahmed S F^*

来源：Clinical Endocrinology, 2014, 80(6): 811-817.

DOI：10.1111/cen.12367

Objective
Traditional methods of bone densitometry may not provide a comprehensive assessment of bone health. We aimed to assess bone micro-architecture and bone marrow adiposity (BMA) by MRI in adults with osteogenesis imperfecta (OI) and endocrinopathy including GH deficiency and/or hypogonadism.
Measurements
High-resolution micro-MRI images were acquired at the tibia using 3T MRI to calculate parameters of bone micro-architecture in seven adults with OI and 10 adults with endocrinopathies. MR Spectroscopy was performed in participants to calculate vertebral BMA, which was expressed as percentage fat fraction (%FF). Lumbar spine DXA was performed to assess bone mineral density. The MRI data were compared with a group of 22 healthy adults who were divided into two age-matched control groups.
Results
Intra-operator repeatability was high, with an average CoV of 1% for micro-MRI and 2 center dot 5% for MRS. The ratio of apparent bone volume to total volume (appBV/TV) in the endocrinopathy and OI groups was lower than in age-matched control groups (P=0 center dot 003 and P=0 center dot 008 respectively). A weak association between DXA BMD and appBV/TV was also observed (r=0 center dot 5, P=0 center dot 045). %FF was higher in the endocrinopathy group than in the age-matched control group (P=0 center dot 005), but no difference in %FF was observed between the OI group and their age-matched control group (P=0 center dot 26).
Conclusions
MRI provides valuable detailed information on the micro-architecture and adiposity of bones and is capable of showing clear differences in bone parameters in a range of clinical conditions associated with abnormal bone health.

• 出版日期2014-6