Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action

作者：Fernandez Alvaro Elena; Hong W David; Nixon Gemma L; O'Neil Paul M; Calderon Felix^*

来源：Journal of Medicinal Chemistry, 2016, 59(12): 5587-5603.

DOI：10.1021/acs.jmedchem.5b01485

Natural products have played a pivotal role in malaria chemotherapy progressing from quinine and artemisinin to ozonide-based compounds. Many of these natural products have served as template for the design and development of antimalarial drugs currently in the clinic or in the development phase. In this review, we will detail those privileged scaffolds that have guided medicinal chemistry efforts yielding molecules that have reached the clinic.

• 出版日期2016-6-23