NF-kappa B: The Inducible Factors of HIV-1 Transcription and their Inhibitors

作者：Yu Mingyan; Liu Xinyong^*; De Clercq Erik

来源：Mini Reviews in Medicinal Chemistry, 2009, 9(1): 60-69.

DOI：10.2174/138955709787001677

• AIDS
• HIV-1
• NF-kappa B
• transcription
• inhibitor
• LTR
• I kappa B
• IKK

NF-kappaB (NF-kappa B), the transcription factors of HIV-1, play an important role in triggering HIV transcription. The inhibition of NF-kappa B activation and their signaling pathway offers a potential anti-HIV therapy strategy. This review reports the mode of action of NF-kappa B in triggering HIV-1 transcription and the status of the inhibitors.

• 出版日期2009-1
• 单位河北医科大学; 山东大学