A new prospect in magnetic nanoparticle-based cancer therapy: Taking credit from mathematical tissue-mimicking phantom brain models

作者：Saeedi Mostafa; Vahidi Omid; Goodarzi Vahabodin^*; Saeb Mohammad Reza^*; Izadi Leila; Mozafari Masoud^*

来源：Nanomedicine: Nanotechnology, Biology and Medicine , 2017, 13(8): 2405-2414.

DOI：10.1016/j.nano.2017.07.013

• Magnetic nanoparticles
• Hyperthermia
• Tissue-mimicking phantoms
• Mathematical model

Distribution patterns/performance of magnetic nanoparticles (MNPs) was visualized by computer simulation and experimental validation on agarose gel tissue-mimicking phantom (AGTMP) models. The geometry of a complex three-dimensional mathematical phantom model of a cancer tumor was examined by tomography imaging. The capability of mathematical model to predict distribution patterns/performance in AGTMP model was captured. The temperature profile vs. hyperthermia duration was obtained by solving bio-heat equations for four different MNPs distribution patterns and correlated with cell death rate. The outcomes indicated that bio-heat model was able to predict temperature profile throughout the tissue model with a reasonable precision, to be applied for complex tissue geometries. The simulation results on the cancer tumor model shed light on the effectiveness of the studied parameters.

• 出版日期2017-11