ANCA-associated vasculitis with dual ANCA positivity in coexistence with mixed connective tissue disease

作者：Murakami Masanori; Shimane Kenichi^*; Takahashi Hiroshi; Tomiyama Junji; Nagashima Masakazu

来源：Modern Rheumatology, 2013, 23(1): 156-161.

DOI：10.1007/s10165-012-0619-8

• Anti-neutrophil cytoplasmic antibody
• HLA-DRB1*09:01
• Microscopic polyangiitis
• Mixed connective tissue disease

We here report a rare case of dual antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a 38-year-old Japanese woman previously diagnosed with mixed connective tissue disease. The patient was found to be positive for myeloperoxidase- and proteinase 3-ANCA, and was diagnosed with AAV following admission to hospital with fervescence, polyarthralgia, purpura, and asymmetric numbness of the extremities. Examination of her genetic background revealed that she carried HLA-DR9, which confers risk of both diseases in Japanese populations.

• 出版日期2013-1