A 3D Homochiral MOF [Cd-2(d-cam)(3)]center dot 2Hdma center dot 4dma for HPLC Chromatographic Enantioseparation

作者：Zhang, Mei; Chen, Xinglian; Zhang, Junhui; Kong, Jiao; Yuan, Liming^*

来源：Chirality, 2016, 28(4): 340-346.

DOI：10.1002/chir.22588

• metal-organic frameworks
• chiral stationary phase
• high-performance liquid chromatography
• racemates
• enantioseparation

Up to now, some chiral metal-organic frameworks (MOFs) have been reported for enantioseparation in liquid chromatography. Here we report a homochiral MOF, [Cd2(d-cam)3]2Hdma4dma, used as a new chiral stationary phase for high-performance liquid chromatographic enantioseparation. Nine racemates of alcohol, naphthol, ketone, and base compounds were used as analytes for evaluating the separation properties of the chiral MOF packed column. Moreover, some effects such as mobile phase composition, column temperature, and analytes mass for separations on this chiral column also were investigated. The relative standard deviations for the resolution values of run-to-run and column-to-column were less than 2.1% and 3.2%, respectively. The experimental results indicate that the homochiral MOF offered good recognition ability, which promotes the application of chiral MOFs use as stationary phase for enantioseparation. Chirality 28:340-346, 2016.

• 出版日期2016-4
• 单位云南师范大学; 云南中医药大学; 华东师范大学