Non-superparamagnetic iron-oxide architectures with controlled T2 contrast ability in magnetic resonance imaging

作者：Ma, Ji; Zhang, Xiaobing; He, Yunhao; Sun, Qinglei; Wang, Yunguo; Zuo-Jiang, Sizhi; Wen, Yizhi; Liu, Ruiyun; Li, Xiaodong; Wang, Xingkai; Dong, Weifeng; Chen, Kezheng^*

来源：Applied Physics Letters, 2015, 107(7): 073701.

DOI：10.1063/1.4928914

• NANOPARTICLES
• MRI
• RELAXATION
• HEMATITE
• RELAXIVITY
• AGENTS

In this work, numerous antiferromagnetic (AFM) and weak ferromagnetic (WFM) iron oxides were fabricated and used as contrast agents in magnetic resonance imaging application. These non-superparamagnetic iron oxides exhibit r(2)/r(1) ratios in a range of 20-110, and hence making them potential for T-2 contrast enhancers. Most strikingly, a Langevin-function relationship was found between r(2)/r(1) ratios and the specific surface area (S) values, r(2)/r(1) similar to L-2 (S-1), which is quite unique for AFM and WFM iron oxides. This finding enables us to precisely tailor their r(2)/r(1) ratios simply by manipulating their specific surface area via controlling morphology and structure in preparation.

• 出版日期2015-8-17
• 单位青岛科技大学