New multimodal data obtained in-vivo from a single ultra-miniature transducer

作者：Clark Therese M^*; Malpas Simon C; McCormick Daniel; Guild Sarah Jane; Budgett David M

来源：Biomedical Microdevices, 2015, 17(4): 72.

DOI：10.1007/s10544-015-9984-3

• Multimodal
• Microsensors
• Multiparameter sensors
• Piezoresistive devices
• Pressure measurement
• Semiconductor devices
• Temperature measurement
• Thermoresistivity
• Telemetry
• Implantable devices

Recent advances in multimodal sensing technology and sensor miniaturization technologies are paving the way for a new era in physiological measurement. Traditional approaches have integrated several transducers on a single silicon chip or packaged several sensing elements within a bio-compatible catheter. Thermal and electrical cross-talk between sensors, time-lag between parallel measurements, lower yields associated with the increased complexity, and restrictions on the minimum size are challenges presented by these approaches. We present an alternative method which enables simultaneous measurement of temperature, pressure and heart rate to be obtained from a single ultra-miniature solid-state transducer. For the first time multimodal data were obtained from the sensor located within the abdominal aortas of five rats. The catheter-tip sensor interfaces with a fully implanted and inductively powered telemetry device capable of operating for the lifetime of the animal. Results of this study demonstrate good agreement between the core-temperature measurement from the catheter-tip sensor and the reference sensor with mean difference between the two sensors of 0.03 degrees C +/- 0.02 degrees C (n=5, 7 days). Real-time data obtained in the undisturbed rat, revealed fluctuations associated with the rest-activity cycle, in temperature, mean arterial pressure and heart rate. The stress response was shown to elicit an elevation in the core temperature of 1.5 degrees C. This was heralded by an elevation in mean arterial pressure of 35 mmHg and heart rate of 160 bpm. Obtaining multiple parameters from a single transducer goes a considerable way towards overcoming challenges of the prior art.

• 出版日期2015-8