An efficient regioselective synthesis of highly functionalized 3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidines via an isocyanide-based three-component reaction

作者：Esmaeili Abbas Ali^*; Zangouei Mandieh; Fakhari Ali Reza; Habibi Azizollah

来源：Tetrahedron Letters, 2012, 53(11): 1351-1353.

DOI：10.1016/j.tetlet.2012.01.005

• 2-Imino-1,3-thiazolidin-4-one
• Dialkyl acetylenedicarboxylates, Alkyl isocyanides
• Thiazolo[3,2-a]pyrimidine

We present a novel, convenient, and efficient method for synthesizing polysubstituted 3-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidines via a three-component reaction. The zwitterions generated from the reaction of isocyanides and dialkyl acetylenedicarboxylates react with 2-imino-1,3-thiazolidin-4-one to produce the title compounds in good yields.

• 出版日期2012-3-14