RETINAL PIGMENT EPITHELIAL TEARS IN RANIBIZUMAB-TREATED EYES

作者：Smith Bradley T; Kraus Courtney L; Apte Rajendra S^*

来源：Retina-The Journal of Retinal and Vitreous Diseases, 2009, 29(3): 335-339.

DOI：10.1097/iae.0b013e318195cad5

• retina
• ranibizumab
• lucentis
• retinal pigment epithelium
• retinal pigment epithelial detachment
• rip
• tear
• neovascular
• age-related macular degeneration
• vascular endothelial growth factor

Purpose: To report the incidence of retinal pigment epithelial (RPE) tears in patients treated with ranibizumab therapy for choroidal neovascularization due to age-related macular degeneration.
Design: Interventional case series.
Methods: One hundred sixty-four eyes from a large clinical practice were retrospectively reviewed for number of injections and the presence or absence of a fibrovascular retinal pigment epithelial detachment. Main outcome measures were occurrence of RPE tears, and timing of tears following the last injection.
Results: Patients were observed for an average of 11 months. A single patient (0.61 %) experienced an RPE tear and this occurred after the first injection. In eyes with a fibrovascular retinal pigment epithelial detachment the incidence was 5%. Lesions containing a fibrovascular retinal pigment epithelial detachment tended to be larger (4.5 versus 3.8 Macular Photocoagulation Study Disc Areas), but this was not statistically significant. (P 0.63). However, these lesions required more injections on average (P = 0.05).
Conclusion: The incidence of RPE tears associated with ranibizumab therapy is low and may result from a predisposition rather than an effect of treatment. Even so, patients undergoing ranibizumab therapy should be counseled regarding this possible complication.

• 出版日期2009-3