Arresting the Inflammatory Drive of Chronic Lymphocytic Leukemia with Ibrutinib

作者:Bachireddy Pavan; Wu Catherine J*
来源:Clinical Cancer Research, 2016, 22(7): 1547-1549.
DOI:10.1158/1078-0432.CCR-15-3106

摘要

The clinical success of agents targeting the B-cell receptor signaling pathway in chronic lymphocytic leukemia (CLL) may also derive from disrupting the CLL microenvironment. Investigation of the immunomodulatory effects of these agents illuminates the unique immunobiology of CLL and highlights potential targets for dismantling the chronic inflammatory drive.

  • 出版日期2016-4-1
  • 单位MIT