Design and fabrication of core-shell gold coated Fe3O4 magnetic nanoparticles as Cancer Cells Targeting agent

作者：Shahnaz Karamipour^*; Nazanin Farhadyar; Mirabdullah Seyed Sadjadi

来源：Research Journal of Biotechnology, 2015, 10(5): 27-33.

• Gold coated materials
• Magnetic properties
• Folate conjugation
• 3-aminothiophenol
• Cancer drug delivery

Core shell gold coated magnetite iron oxide nanoparticles can be used in biomedical applications such as magnetic bioseparation, bioimaging, drug delivery and cancer cell treatment. In this work, we synthesized gold coated magnetic nanoparticles in various molar ratios of Fe3O4 and gold using magnetite nanoparticles prepared in an average size of 5.6 nm diameter by a simple chemical co-precipitation method. Prepared nanostructure was then functionalized by 3-aminothiophenol (3-ATP) and folate-conjugated to prepare folate receptor targets on the tumoral cells surface. Characterization of gold coated magnetic nanoparticles was carried out by various techniques such as X-ray powder diffraction (XRD) analysis, Fourier transform infrared (FT-IR) and UV-visible spectroscopy, Field emission scanning electron microscopy (FESEM) and finally Vibrating Sample Magnetometer (VSM) analysis. The results indicated attachment of the functional agent, 3-ATP on the surface gold nanoparticle through thiol groups and its conjugation with folic acid via amine group of 3-aminothiophenol.

• 出版日期2015-5