High Proportion of Leukemic Stem Cells at Diagnosis Is Correlated with Unfavorable Prognosis in Childhood Acute Myeloid Leukemia

作者：Witte Kai Erik; Ahlers Joerg; Schaefer Iris; Andre Maya; Kerst Gunter; Scheel Walter Hans Gerhard; Schwarze Carl Philipp; Pfeiffer Matthias; Lang Peter; Handgretinger Rupert; Ebinger Martin^*

来源：Pediatric Hematology and Oncology, 2011, 28(2): 91-99.

DOI：10.3109/08880018.2010.528171

In acute myeloid leukemia (AML), the leukemia-initiating cell is found within the CD34 0.83%%; log-rank P < .04). This correlation was not found for the total number of CD34<SU++</SU cells. This is the first study to show that a higher proportion of immature CD34<SU++</SU/CD38<SU--</SU/CD45<SU--/low</SU blasts at diagnosis correlates with unfavorable prognosis in childhood AML. The results suggest that a large CD34<SU++</SU/CD38<SU--</SU/CD45<SU--/low</SU population reflects a higher fraction of LSCs, leading to increased chemotherapy resistance and elevated relapse rate. Thus the initial frequency of CD34<SU++</SU/CD38<SU--</SU/CD45<SU--/low</SU cells may serve as a prognostic marker in pediatric AML. Future treatment in childhood AML should specifically target this immature population as well as the mature blast population.</.

• 出版日期2011-3